Medications Interacting

Sometimes, people are prescribed pain medication because the source of pain has already been removed, but tenderness, soreness or down right painful sensations may still linger on for up to a few more days. In these cases, pain medication is the only known way of getting relief. However, patients are sometimes reluctant or down right unwilling to take the medication as they fear it may react with something that they are already taking or plan on taking. Here is a list of some of the things that pain medications interact with, and some that they do not. I am assuming that the painkillers are codeine based, or based off of some other synthetic opiate, as these are usually the ones that are used.

Birth Control

No problem. Birth control, none of the types of them react chemically with opiates at all. Women who take birth control are more likely to experience blood clots, and pain medication may also carry this risk, so it may be a bad idea to take pain medicine if you are taking birth control pills and have a history of blood clot related injuries or death in your family; otherwise, knock yourself out.

Blood thinners

Many pain medications are also blood thinners, like Ibuprofen, but most blood thinning pain medication is over the counter. The really good stuff prescribed by dentists usually do not cause the blood to thin out at all. Always tell the dentist of any and all medication you take.

Heart Medication

This depends, but most analgesics work completely well with opioids, indeed, opiates can be prescribed to treat certain heart conditions. But this is only one of the many subsets of medications designed to deal with heart related issues, and whether or not pain medication will interact is something that the doctor should know. 


Painkillers and antidepressants work to reach the same parts of the brain, and can frequently cause interactions. For instance, many times they cancel each other out, when experiencing pain, and taking pain medication, the effects of the antidepressants may become void, and vice versa. However, many people report feeling less pain when on antidepressants, or of feeling euphoric when taking pain medication, and we know there is a biochemical link between pain and depression, but it is not well understood as of now.


Anti-anxiety medications as well as many sleep aids are made from benzodiazepines, a class of psychoactive drugs that are taken in small doses to cause the patient to be calm and stress free. However, these medications almost always interact with opioids to produce a powerful and intoxicating mixture that frequently causes psychotic episodes and loss of cognitive functions. Tell your dentist if you are taking benzodiazepines, as they need to know what you take in order to make sure that an unwanted drug interaction does not happen. 

image: 1.